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Cancer cells not only switch from OXPHOS to lactate-dependent energy-generating pathways, but also upregulate antioxidant-related genes [e.g., NF-E2-related factor 2 (Nrf2)] to overcome a wide range of oxidative stress [27]

Y., Wu, Y., Begley, T

171 In a tumor environment, tumor immune escape mechanisms will clear eATP to avoid inflammasome and inflammation reaction, therefore, CD39 antibody which inhibits ATP transformation to AMP could enhance ATP-mediated activation of inflammasomes and the corresponding inflammatory response

8 In 1939, caloric restriction was subsequently reported to have extended the lifespan of rats and mice, 9 which was the first evidence that the aging process was regulated (Fig

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